4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:原厂直采,平行进口,授权代理(蚂蚁淘为您服务)
咨询热线电话
4000-520-616
当前位置: 首页 > 新闻动态 >
新闻详情
...structures towards hydrolysis in aqueous solutions RID A...
来自 : www.onacademic.com/detail/jour 发布时间:2021-03-25
Bioreversible derivatives of phenol. 2. Reactivity of carbonate esters with fatty acid-like structures towards hydrolysis in aqueous solutions RID A-9922-2011 Author: Ostergaard, JesperLarsen, Claus

Journal: MOLECULES

Issue Date: 2007

Abstract(summary):
A series of model phenol carbonate ester prodrugs encompassing derivatives with fatty acid-like structures were synthesized and their stability as a function of pH ( range 0.4-12.5) at 37 degrees C in aqueous buffer solutions investigated. The hydrolysis rates in aqueous solutions differed widely, depending on the selected pro-moieties ( alkyl and aryl substituents). The observed reactivity differences could be rationalized by the inductive and steric properties of the substituent groups when taking into account that the mechanism of hydrolysis may change when the type of pro-moiety is altered, e. g. n-alkyl vs. t-butyl. Hydrolysis of the phenolic carbonate ester 2-(phenoxycarbonyloxy)-acetic acid was increased due to intramolecular catalysis, as compared to the derivatives synthesized from omega-hydroxy carboxylic acids with longer alkyl chains. The carbonate esters appear to be less reactive towards specific acid and base catalyzed hydrolysis than phenyl acetate. The results underline that it is unrealistic to expect that phenolic carbonate ester prodrugs can be utilized in ready to use aqueous formulations. The stability of the carbonate ester derivatives with fatty acid-like structures, expected to interact with the plasma protein human serum albumin, proved sufficient for further in vitro and in vivo evaluation of the potential of utilizing HSA binding in combination with the prodrug approach for optimization of drug pharmacokinetics.

Page: 2396---2412

本文链接: http://biobuffersolutions.immuno-online.com/view-733189.html

发布于 : 2021-03-25 阅读(0)
公司介绍
联络我们
服务热线:4000-520-616
(限工作日9:00-18:00)
QQ :1570468124
手机:18915418616
官网:http://
  • 服务热线:
    4000-520-616

    固话:
    0512-67156496

    手机:
    18915418616

    邮箱:
    info@ebiomall.com
    工作时间:
    9:00 - 18:00
  • -平行进口 原厂直采-

    立即搜索

    我们与欧美近百家中小品牌签订代理,近千家海外生物有合作,可以帮忙代购,免费询价.您也可以加入我们QQ群[616054153]
    或者扫上面微信[ebiomall08],加我好友,备注:进群,我们会第一时间拉你进销售咨询群
  • 收起>>